![]() The associations were specific to biomarkers measured during the acute (rather than post-acute) phase and they cannot be accounted for simply by more severe illness (as there was no mediation by severity of the acute illness) nor by pre-existing cognitive deficits. High D-dimer levels were linked with occupational impairment at 6 and 12 months, while fibrinogen was not. High levels of fibrinogen were correlated with both objective and subjective cognitive impairment, and high levels of D-dimer were correlated with subjective cognitive deficits such as brain fog and occupational impairment mediated by fatigue, as well as shortness of breath.Įlevated levels of both biomarkers occurred in patients with lower-than-expected levels of CRP, when levels of both are typically correlated at the cohort level. Two blood-clotting protein profiles were highly correlated with persistent cognitive impairment. ![]() "Among these symptoms, cognitive deficits (including 'brain fog') are particularly worrisome they are common, persistent and they affect the ability to work." Brain fog, occupational problems "One in eight patients receives their first ever neurological or psychiatric diagnosis within 6 months following COVID-19," the researchers wrote. Average patient age was 57.9 years, and 36.6% were women. The team collected blood samples from patients at hospital admission and gathered clinician- and patient-acquired measurements of cognition 6 and 12 months later. University of Oxford researchers identified two profiles related to elevated levels of the biomarkers fibrinogen and D-dimer relative to C-reactive protein (CRP) in 1,837 hospitalized adults who tested positive for COVID-19 in the United Kingdom from January 2020 to November 2021. The findings, the authors said, provide further insights into the diverse biologic factors involved in post-COVID cognitive deficits. High levels of two blood biomarkers during infection could predict cognitive dysfunction, or "brain fog," among COVID-19 survivors 6 and 12 months after hospitalization, according to a UK study published yesterday in Nature Medicine.
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